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  Differences in magnesium and calcium effects on N-methyl-D-aspartate- and quisqualate-induced decreases in extracellular sodium concentration in rat hippocampal slices

Köhr, G., & Heinemann, U. (1988). Differences in magnesium and calcium effects on N-methyl-D-aspartate- and quisqualate-induced decreases in extracellular sodium concentration in rat hippocampal slices. Experimental Brain Research, 71(2), 425-430. doi:10.1007/BF00247502.

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ExpBrainRes_71_1988_425.pdf (Any fulltext), 557KB
 
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Köhr, Georg1, 2, 3, Author              
Heinemann, Uwe, Author
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Directly responsible to the Managing Director, Max Planck Institute for Medical Research, Max Planck Society, ou_persistent22              
3Georg Köhr Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497714              

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Free keywords: Extracellular Na+ concentration; Quisqualate (quis); N-methyl-D-aspartate (NMDA); Tetrodotoxin (TTX); Hippocampal area CA1; Rat; Extracellular Ca2+ concentration; Extracellular Mg2+ concentration
 Abstract: Decreases in extracellular sodium concentration [( Na+]o) and associated slow negative field potentials (fp's) were monitored with double barreled sodium sensitive/reference microelectrodes in area CA1 of rat hippocampal slices during iontophoretic application of the glutamate receptor agonists N-methyl-D-aspartate (NMDA) and quisqualate (quis). The effects of lowering [Ca2+]o on these signals were compared to those of lowering [Mg2+]o. Both NMDA- and quis-induced decreases in [Na+]o of up to 60 mM and in the fp's of up to 8 mV. Decreasing [Mg2+]o enhanced NMDA-induced signals, whereas quis-induced signals were unaffected. Lowering [Ca2+]o also enhanced NMDA signals, although somewhat less than lowering [Mg2+]o. This effect was still present, even when voltage dependent Na+ currents were blocked by 10(-7) tetrodotoxin. Interestingly, quis-induced signals could be enhanced in a low Ca2+ medium as well, but only when high quis concentrations were used. The results suggest that, during the sorts of large decreases of [Ca2+]o observed during seizure activity, activation of NMDA receptors is facilitated.

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Language(s): eng - English
 Dates: 1987-07-201988-02-041988
 Publication Status: Published in print
 Pages: 6
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 Rev. Type: Peer
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Title: Experimental Brain Research
  Other : Exp. Brain Res.
Source Genre: Journal
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Publ. Info: Heidelberg : Springer-Verlag
Pages: - Volume / Issue: 71 (2) Sequence Number: - Start / End Page: 425 - 430 Identifier: ISSN: 0014-4819
CoNE: https://pure.mpg.de/cone/journals/resource/954925398496