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  Tailored environments to study motile cells and pathogens

Muthinja, J. M., Ripp, J., Krüger, T., Imle, A., Haraszti, T., Fackler, O., et al. (2018). Tailored environments to study motile cells and pathogens. Cellular Microbiology, 20(3): e12820, pp. 1-10. doi:10.1111/cmi.12820.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-B8EF-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-6C1E-5
Genre: Journal Article

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 Creators:
Muthinja, Julianne Mendi, Author
Ripp, Johanna, Author
Krüger, Timothy, Author
Imle, Andrea, Author
Haraszti, Tamas1, 2, Author              
Fackler, Oliver, Author
Spatz, Joachim P.1, 2, Author              
Engstler, Markus, Author
Frischknecht, Friedrich, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Motile cells and pathogens migrate in complex environments and yet are mostly studied on simple 2D substrates. In order to mimic the diverse environments of motile cells, a set of assays including substrates of defined elasticity, microfluidics, micropatterns, organotypic cultures, and 3D gels have been developed. We briefly introduce these and then focus on the use of micropatterned pillar arrays, which help to bridge the gap between 2D and 3D. These structures are made from polydimethylsiloxane, a moldable plastic, and their use has revealed new insights into mechanoperception in Caenorhabditis elegans, gliding motility of Plasmodium, swimming of trypanosomes, and nuclear stability in cancer cells. These studies contributed to our understanding of how the environment influences the respective cell and inform on how the cells adapt to their natural surroundings on a cellular and molecular level.

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Language(s): eng - English
 Dates: 2017-12-112017-10-092018-01-072018-02-09
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Cellular Microbiology
Source Genre: Journal
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Publ. Info: Malden, MA : Blackwell Science
Pages: - Volume / Issue: 20 (3) Sequence Number: e12820 Start / End Page: 1 - 10 Identifier: ISSN: 1462-5814
CoNE: https://pure.mpg.de/cone/journals/resource/959328105032