English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals

Hecker, N., Sharma, V., & Hiller, M. (2017). Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals. Genome Biology and Evolution, 9(11), 3179-3188. doi:10.1093/gbe/evx239.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-BB34-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-9F3E-8
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Hecker, Nikolai1, Author              
Sharma, Virag1, Author              
Hiller, Michael1, Author              
Affiliations:
1Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288              

Content

show
hide
Free keywords: -
 MPIPKS: Living matter
 Abstract: Kallikrein related peptidase 8 (KLK8; also called neuropsin) is a serine protease that plays distinct roles in the skin and hippocampus. In the skin, KLK8 influences keratinocyte proliferation and desquamation, and activates antimicrobial peptides in sweat. In the hippocampus, KLK8 affects memory acquisition. Here, we examined the evolution of KLK8 in mammals and discovered that, out of 70 placental mammals, KLK8 is exclusively lost in three independent fully-aquatic lineages, comprising dolphin, killer whale, minke whale, and manatee. In addition, while the sperm whale has an intact KLK8 reading frame, the gene evolves neutrally in this species. We suggest that the distinct functions of KLK8 likely became obsolete in the aquatic environment, leading to the subsequent loss of KLK8 in several fully-aquatic mammalian lineages. First, the cetacean and manatee skin lacks sweat glands as an adaptation to the aquatic environment, which likely made the epidermal function of KLK8 obsolete. Second, cetaceans and manatees exhibit a proportionally small hippocampus, which may have rendered the hippocampal functions of KLK8 obsolete. Together, our results shed light on the genomic changes that correlate with skin and neuroanatomical differences of aquatic mammals, and show that even pleiotropic genes can be lost during evolution if an environmental change nullifies the need for the different functions of such genes.

Details

show
hide
Language(s): eng - English
 Dates: 2017-11-142017-11-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000423459700020
DOI: 10.1093/gbe/evx239
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genome Biology and Evolution
  Other : GBE
  Abbreviation : Genome Biol Evol
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Oxford Univ. Press
Pages: - Volume / Issue: 9 (11) Sequence Number: - Start / End Page: 3179 - 3188 Identifier: Other: 1759-6653
CoNE: /journals/resource/1759-6653