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  Structural and functional basis for GABAA receptor heterogeneity

Levitan, E. S., Schofield, P. R., Burt, D. R., Rhee, L. M., Wisden, W., Köhler, M., et al. (1988). Structural and functional basis for GABAA receptor heterogeneity. Nature, 335, 76-79. doi:10.1038/335076a0.

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Levitan, Edwin S., Author
Schofield, Peter R., Author
Burt, David R., Author
Rhee, Lucy M., Author
Wisden, William, Author
Köhler, Martin1, Author           
Rodriguez, Henry F., Author
Stevenson, F. A., Author
Darlison, Mark G., Author
Barnard, Eric A., Author
Seeburg, Peter H.1, Author           
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1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: When gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. Neurotransmitter action at the GABAA receptor is potentiated by both benzodiazepines and barbiturates which are therapeutically useful drugs (reviewed in ref. 1). There is strong evidence that this receptor is heterogeneous. We have previously isolated complementary DNAs encoding an alpha- and a beta-subunit and shown that both are needed for expression of a functional GABAA receptor. We have now isolated cDNAs encoding two additional GABAA receptor alpha-subunits, confirming the heterogeneous nature of the receptor/chloride channel complex and demonstrating a molecular basis for it. These alpha-subunits are differentially expressed within the CNS and produce, when expressed with the beta-subunit in Xenopus oocytes, receptor subtypes which can be distinguished by their apparent sensitivity to GABA. Highly homologous receptor subtypes which differ functionally seem to be a common feature of brain receptors.

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Language(s): eng - English
 Dates: 1988-03-211988-07-191988-09-01
 Publication Status: Issued
 Pages: 4
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 Rev. Type: Peer
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 335 Sequence Number: - Start / End Page: 76 - 79 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238