English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Dormancy: an evolutionary key phenomenon in cancer development

Ammerpohl, O., Hattermann, K., Held-Feindt, J., Röcken, C., Schäfer, H., Schem, C., et al. (2017). Dormancy: an evolutionary key phenomenon in cancer development. In B. Ujavari, & B. Roche (Eds.), ECOLOGY AND EVOLUTION OF CANCER (pp. 235-242). London, UK: Academic Press, Elsevier. doi:10.1016/B978-0-12-804310-3.00020-X.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-C6D2-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7E6B-B
Genre: Book Chapter
Other : Chapter 20 – Dormancy: An Evolutionary Key Phenomenon in Cancer Development

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Ammerpohl, Ole, Author
Hattermann, Kirsten, Author
Held-Feindt, Janka, Author
Röcken, Christoph, Author
Schäfer, Heiner, Author
Schem, Christian, Author
Schewe, Denis, Author
Schulenburg, Hinrich, Author
Sebens, Susanne, Author
Synowitz, Michael, Author
Tiwari, Sanjay, Author
Traulsen, Arne1, Author              
Trauzold, Anna, Author
Valerius, Thomas, Author
Wesch, Daniela, Author
Affiliations:
1Department Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

Content

show
hide
Free keywords: Dormancy; Life-history phases; Population heterogeneity; Reversible quiescence; Tumor evolution
 Abstract: Dormancy has been defined as "one of two prerequisites for life" and plays a fundamental role in all stages of tumor evolution. Described as a reversible quiescent cellular stage, tumor dormancy allows adaptation and survival of tumor cells under hostile conditions, for example, oxidative or metabolic stress, inflammatory processes or exposure to anticancer therapies. Thus, dormant tumor cells are fundamental for the fitness of the entire tumor cell population assuring and promoting tumor evolution so that dormancy has been postulated as a novel hallmark of cancer. Besides the tumoral microenvironment, epigenetic, and metabolic alterations seem to be critical determinants for the entry in and exit from dormancy. However, the underlying mechanisms are still poorly understood. In fact, dormant life-history phases or stages are widespread among living organisms representing a highly effective strategy to survive unfavorable environmental conditions and thus ensuring persistence during evolution. Integrating an evolutionary perspective in the investigation of tumor dormancy will help us to understand the plasticity of the proliferative phenotype of tumor cells and how this promotes tumor evolution. Incorporating evolutionary methods into cancer research and addressing new evolutionary questions may help to explain the phenomenon of dormancy in tumor evolution leading to improved cancer therapies. © 2017 Elsevier Inc. All rights reserved.

Details

show
hide
Language(s): eng - English
 Dates: 2017-02-242017
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: ECOLOGY AND EVOLUTION OF CANCER
Source Genre: Book
 Creator(s):
Ujavari, Beata, Editor
Roche, Benjamin, Editor
Thomas, Frédéric, Author
Affiliations:
-
Publ. Info: London, UK : Academic Press, Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 235 - 242 Identifier: ISBN: 978-0-12-804310-3