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  Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1

Brunner, B., Hornung, U., Shan, Z., Nanda, I., Kondo, M., Zend-Ajusch, E., et al. (2001). Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1. Genomics, 77(1-2), 8-17. doi:10.1006/geno.2001.6615.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E03A-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E03B-F
Genre: Journal Article

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 Creators:
Brunner, B.1, Author
Hornung, U.1, Author
Shan, Z.1, Author
Nanda, I.1, Author
Kondo, M.1, Author
Zend-Ajusch, E.1, Author
Haaf, T.1, Author
Ropers, H. H.1, Author
Shima, A.1, Author
Schmid, M.1, Author
Kalscheuer, V. M.1, Author
Schartl, M.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Amino Acid Sequence Animals Base Sequence Chromosome Mapping Chromosomes/genetics Chromosomes, Human, Pair 9/genetics Conserved Sequence DNA/chemistry/genetics DNA, Complementary/chemistry/genetics *DNA-Binding Proteins Exons Female Fishes/embryology/genetics Gene Expression Gene Expression Regulation, Developmental Genes/*genetics Humans In Situ Hybridization, Fluorescence Introns Male Molecular Sequence Data Multigene Family/*genetics Oryzias/embryology/genetics Protein Isoforms/genetics RNA/genetics/metabolism Regulatory Sequences, Nucleic Acid/*genetics Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Tissue Distribution Transcription Factors/*genetics *Zebrafish Proteins
 Abstract: Genes related to the Drosophila melanogaster doublesex and Caenorhabditis elegans mab-3 genes are conserved in human. They are identified by a DNA-binding homology motif, the DM domain, and constitute a gene family (DMRTs). Unlike the invertebrate genes, whose role in the sex-determination process is essentially understood, the function of the different vertebrate DMRT genes is not as clear. Evidence has accumulated for the involvement of DMRT1 in male sex determination and differentiation. DMRT2 (known as terra in zebrafish) seems to be a critical factor for somitogenesis. To contribute to a better understanding of the function of this important gene family, we have analyzed DMRT1, DMRT2, and DMRT3 from the genome model organism Fugu rubripes and the medakafish, a complementary model organism for genetics and functional studies. We found conservation of synteny of human chromosome 9 in F. rubripes and an identical gene cluster organization of the DMRTs in both fish. Although expression analysis and gene linkage mapping in medaka exclude a function for any of the three genes in the primary step of male sex determination, comparison of F. rubripes and human sequences uncovered three putative regulatory regions that might have a role in more downstream events of sex determination and human XY sex reversal.

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 Dates: 2001
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 11543627
DOI: 10.1006/geno.2001.6615
ISSN: 0888-7543 (Print) 0888-7543 (Linking)
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Title: Genomics
  Alternative Title : Genomics
Source Genre: Journal
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Pages: - Volume / Issue: 77 (1-2) Sequence Number: - Start / End Page: 8 - 17 Identifier: -