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  The MAS proto-oncogene is not imprinted in humans

Riesewijk, A. M., Schepens, M. T., Mariman, E. M., Ropers, H. H., & Kalscheuer, V. M. (1996). The MAS proto-oncogene is not imprinted in humans. Genomics, 35(2), 380-2. doi:10.1006/geno.1996.0372.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0002-E019-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0002-E01A-4
Genre: Journal Article

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 Creators:
Riesewijk, A. M.1, Author
Schepens, M. T.1, Author
Mariman, E. M.1, Author
Ropers, H. H.1, Author
Kalscheuer, V. M.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Alleles Animals Base Sequence Chromosome Mapping Chromosomes, Artificial, Yeast *Chromosomes, Human, Pair 6 DNA Primers *Embryonic and Fetal Development Female *Gene Expression Regulation, Developmental *Genomic Imprinting Humans Male Mice Molecular Sequence Data Organ Specificity Polymerase Chain Reaction Polymorphism, Genetic Pregnancy Protein-Tyrosine Kinases/genetics Proto-Oncogene Proteins/*biosynthesis/*genetics *Proto-Oncogenes Receptor, IGF Type 2/biosynthesis/genetics Receptors, G-Protein-Coupled Transcription, Genetic
 Abstract: Recently it was shown that the murine Mas gene, which is located less than 300 kb from the imprinted Igf2r gene, is also imprinted in Day 11.5 embryos with expression exclusively from the paternal allele. We have assigned the human MAS gene to chromosomal bands 6q25.3-q26 in close proximity to the IGF2R gene. In contrast to its murine homologue, the human IGF2R gene is not imprinted. By making use of a novel intragenic polymorphism, we have studied the expression of the MAS gene in three heterozygous human fetuses. In all tissues examined, including tongue, biallelic expression of the MAS gene was observed. Hence both MAS and the neighboring IGF2R gene are not imprinted in humans.

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 Dates: 1996
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: Other: 8661154
DOI: 10.1006/geno.1996.0372
ISSN: 0888-7543 (Print) 0888-7543 (Linking)
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Title: Genomics
  Alternative Title : Genomics
Source Genre: Journal
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Pages: - Volume / Issue: 35 (2) Sequence Number: - Start / End Page: 380 - 2 Identifier: -