English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. Item Summary / 
  2. View item

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

Qu, Y., Easson, M. L. A. E., Simionescu, R., Hajicek, J., Thamm, A. M. K., Salim, V., et al. (2018). Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine. Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3180-3185. doi:10.1073/pnas.1719979115.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0000-C987-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-F1C5-9
Genre: Journal Article

Files

show Files
hide Files
:
EXT555s2.xlsx (Supplementary material), 33KB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0000-C98A-2
Name:
EXT555s2.xlsx
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
https://creativecommons.org/licenses/by/4.0/
:
EXT555.pdf (Publisher version), 2MB
View   Save
File Permalink:
https://hdl.handle.net/21.11116/0000-0000-F9CA-4
Name:
EXT555.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
https://creativecommons.org/licenses/by/4.0/

Locators

show
hide
Locator:
http://dx.doi.org/10.1073/pnas.1719979115 (Publisher version)
Description:
OA
OA-Status:

Creators

show
hide
 Creators:
Qu, Yang, Author
Easson, Michael L. A. E.1, Author           
Simionescu, Razvan, Author
Hajicek, Josef, Author
Thamm, Antje M. K., Author
Salim, Vonny, Author
De Luca, Vincenzo, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Monoterpenoid indole alkaloids (MIAs) possess a diversity of alkaloid skeletons whose biosynthesis is poorly understood. A
bioinformatic search of candidate genes, combined with their
virus-induced gene silencing, targeted MIA profiling and in vitro/
in vivo pathway reconstitution identified and functionally characterized
six genes as well as a seventh enzyme reaction required for
the conversion of 19E-geissoschizine to tabersonine and catharanthine.
The involvement of pathway intermediates in the formation
of four MIA skeletons is described, and the role of stemmadenine-
O-acetylation in providing necessary reactive substrates for the
formation of iboga and aspidosperma MIAs is described. The results
enable the assembly of complex dimeric MIAs used in cancer
chemotherapy and open the way to production of many other
biologically active MIAs that are not easily available from nature

Details

show
hide
Language(s):
 Dates: 2018-03-062018-03
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: EXT555
DOI: 10.1073/pnas.1719979115
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 115 (12) Sequence Number: - Start / End Page: 3180 - 3185 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230