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  A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone

Nikolics, K., Mason, A. J., Szonyi, É., Ramachandran, J., & Seeburg, P. H. (1985). A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone. Nature, 316, 511-517. doi:10.1038/316511a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-CF02-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-CF03-4
Genre: Journal Article

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Nature_316_1985_511.pdf (Any fulltext), 766KB
 
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https://www.nature.com/articles/316511a0.pdf (Any fulltext)
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 Creators:
Nikolics, Károly, Author
Mason, Anthony J., Author
Szonyi, Éva, Author
Ramachandran, J., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins in rat pituitary cell cultures. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion in rabbits.

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Language(s): eng - English
 Dates: 1985-03-081985-06-061985-08-08
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/316511a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/2863757
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 316 Sequence Number: - Start / End Page: 511 - 517 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238