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  Comparative sequence analysis of duck and human hepatitis B virus genomes

Sprengel, R., Kuhn, C., Will, H., & Schaller, H. (1985). Comparative sequence analysis of duck and human hepatitis B virus genomes. Journal of Medical Virology, 15(4), 323-333. doi:10.1002/jmv.1890150402.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-CF05-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-CF06-1
Genre: Journal Article

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JMedVirol_15_1985_323.pdf (Any fulltext), 2MB
 
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http://onlinelibrary.wiley.com/doi/10.1002/jmv.1890150402/epdf (Any fulltext)
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 Creators:
Sprengel, Rolf1, 2, 3, Author           
Kuhn, Christa, Author
Will, Hans, Author
Schaller, Heinz, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Rolf Sprengel Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497741              
3Olfaction Web, Max Planck Institute for Medical Research, Max Planck Society, ou_1497733              

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Free keywords: DHBV cloning; hepatitis B virus; HbcAg; HbsAg; reverse transcriptase
 Abstract: We have cloned and sequenced an infectious, functionally active genome of a duck hepatitis B virus (DHBV). It is 3,021 base pairs (bp) in length and shows little DNA sequence homology to the genome of human hepatitis B virus (HBV). However, the amino acid sequences of predicted viral gene products are similar between DHBV and HBV, and the genome organization present in DHBV reflects that of HBV. As in the mammalian virus the long minus strand of the DHBV genome encodes three long overlapping reading frames designated as P, S, and C. The fourth open reading frame, termed X, is absent in DHBV. A comparison with a sequence of a second DHBV isolate [Mandart et al, Journal of Virology 49:782-792, 1984] revealed a nucleotide sequence variation of 5.6% and confirmed the presented overall gene organization of DHBV.

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Language(s): eng - English
 Dates: 19841984-08-151985-08
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/jmv.1890150402
URI: https://www.ncbi.nlm.nih.gov/pubmed/3981148
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Title: Journal of Medical Virology
  Alternative Title : J. Med. Virol.
Source Genre: Journal
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Publ. Info: Bognor Regis [u.a.] : Wiley
Pages: - Volume / Issue: 15 (4) Sequence Number: - Start / End Page: 323 - 333 Identifier: ISSN: 1096-9071