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Free keywords:
Brønsted acids; cinnamates; Mukaiyama–Michael reaction; organocatalysis; silyl ketene acetals
Abstract:
α,β-Unsaturated esters are readily available but challenging substrates to activate in asymmetric catalysis. We now describe an efficient, general, and highly enantioselective Mukaiyama–Michael reaction of silyl ketene acetals with α,β-unsaturated methyl esters that is catalyzed by a silylium imidodiphosphorimidate (IDPi) Lewis acid.