Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans

Schüler, R., Seebeck, N., Osterhoff, M. A., Witte, V., Flöel, A., Busjahn, A., et al. (2018). VEGF and GLUT1 are highly heritable, inversely correlated and affected by dietary fat intake: Consequences for cognitive function in humans. Molecular Metabolism, 11, 129-136. doi:10.1016/j.molmet.2018.02.004.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Schueler_Seebeck_2017.pdf (Verlagsversion), 839KB
Name:
Schueler_Seebeck_2017.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Schüler, Rita1, 2, Autor
Seebeck, Nicole1, Autor
Osterhoff, Martin A.1, 2, 3, Autor
Witte, Veronica4, 5, 6, Autor           
Flöel, Agnes4, 5, 7, Autor
Busjahn, Andreas8, Autor
Jais, Alexander9, 10, 11, Autor
Brüning, Jens C.2, 9, 10, 11, Autor
Frahnow, Turid1, Autor
Kabisch, Stefan1, 2, 3, Autor
Pivovarova, Olga1, 2, 3, Autor
Hornemann, Silke1, Autor
Kruse, Michael1, 3, Autor
Pfeiffer, Andreas F. H.1, 2, 3, Autor
Affiliations:
1Department of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany, ou_persistent22              
2German Center for Diabetes Research, Neuherberg, Germany, ou_persistent22              
3Clinic of Endocrinology, Diabetes and Nutrition, Charité University Medicine Berlin, Germany, ou_persistent22              
4Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
5NeuroCure Cluster of Excellence, Charité University Medicine Berlin, Germany, ou_persistent22              
6Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
7Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
8HealthTwiSt GmbH, Berlin, Germany, ou_persistent22              
9Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany, ou_persistent22              
10Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Germany, ou_persistent22              
11Center of Molecular Medicine Cologne (CMMC), University of Cologne, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: VEGF; GLUT1; High fat diet; Cognition
 Zusammenfassung: Objective

Reduction of brain glucose transporter GLUT1 results in severe neurological dysfunction. VEGF is required to restore and maintain brain glucose uptake across the blood brain barrier via GLUT1, which was shown to be acutely diminished in response to a high fat diet (HFD) in mice. The genetic and HFD-related regulation and association of VEGF and GLUT1 (SLC2A1) in humans was investigated in the NUtriGenomic Analysis in Twins (NUGAT) study.
Methods

92 healthy and non-obese twins were standardized to a high-carbohydrate low-fat diet for 6 weeks before switched to a 6-week HFD under isocaloric conditions. Three clinical investigation days were conducted: after 6 weeks of low-fat diet and after 1 and 6 weeks of HFD. Serum VEGF and other cytokine levels were measured using ELISA. Gene expression in subcutaneous adipose tissue was assessed by quantitative Real-Time PCR. Genotyping was performed using microarray. The Auditory Verbal Learning Task was conducted to measure cognitive performance.
Results

In this human study, we showed that the environmental regulation of SLC2A1 expression and serum VEGF by HFD was inversely correlated and both factors showed strong heritability (>90%). In response to the HFD containing 45% fat, serum VEGF levels increased (P = 0.002) while SLC2A1 mRNA expression in adipose tissue decreased (P = 0.001). Higher BMI was additionally associated with lower SLC2A1 expression. AA-genotypes of the rs9472159 polymorphism, which explained ∼39% of the variation in circulating VEGF concentrations, showed significantly reduced serum VEGF levels (P = 6.4 × 10−11) but higher SLC2A1 expression (P = 0.009) in adipose tissue compared to CC/CA-genotypes after 6 weeks of HFD. Memory performance in AA-genotypes declined in response to the HFD compared to CC- and CA-genotypes.
Conclusions

The results provide evidence to suggest the translatability of the dietary regulation of VEGF and GLUT1 from mouse models to humans. Our data demonstrate that HFD induces a genetically determined and correlated decrease of GLUT1 and increase of VEGF which may affect memory performance.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2018-02-022017-12-192018-02-062018-02-122018-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.molmet.2018.02.004
PMID: 29506909
PMC: PMC6001408
Anderer: Epub 2018
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : 0315424
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)

Quelle 1

einblenden:
ausblenden:
Titel: Molecular Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam, Netherlands : Elsevier B.V.
Seiten: - Band / Heft: 11 Artikelnummer: - Start- / Endseite: 129 - 136 Identifikator: ISSN: 2212-8778
CoNE: https://pure.mpg.de/cone/journals/resource/2212-8778