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  Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events

Hämmerer, D., Callaghan, M. F., Hopkins, A., Kosciessa, J., Betts, M., Cardenas-Blanco, A., et al. (2018). Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events. Proceedings of the National Academy of Sciences of the United States of America, 115(9), 2228-2233. doi:10.1073/pnas.1712268115.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-D069-F Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A4A9-5
Genre: Journal Article

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 Creators:
Hämmerer, Dorothea1, 2, 3, Author
Callaghan, Martina F.2, Author
Hopkins, Alexandra1, 2, Author
Kosciessa, Julian1, 4, Author
Betts, Matthew3, 5, Author
Cardenas-Blanco, Arturo3, 5, Author
Kanowski, Martin6, Author
Weiskopf, Nikolaus2, 7, Author              
Dayan, Peter8, Author
Dolan, Raymond J.2, 9, Author
Düzel, Emrah1, 3, 6, Author
Affiliations:
1Institute of Cognitive Neuroscience, University College London, United Kingdom, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
3German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              
4Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, ou_persistent22              
5Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
6Department of Neurology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
7Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
8Gatsby Computational Neuroscience Unit, University College London, United Kingdom, ou_persistent22              
9Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom, ou_persistent22              

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Free keywords: Locus coeruleus; Aging; Noradrenaline; Episodic memory; Pupillometry
 Abstract: The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC structural integrity and pupillometry as a putative index of LC activation in both younger and older adults. We show that older adults with reduced structural LC integrity show poorer subsequent memory. This effect is more pronounced for emotionally negative events, in accord with a greater role for noradrenergic modulation in encoding salient or aversive events. In addition, we found that salient stimuli led to greater pupil diameters, consistent with increased LC activation during the encoding of such events. Our study presents novel evidence that a decrement in noradrenergic modulation impacts on specific components of cognition in healthy older adults. The findings provide a strong motivation for further investigation of the effects of altered LC integrity in pathological aging.

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Language(s): eng - English
 Dates: 2017-07-102017-12-272018-02-122018-02-27
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.1712268115
PMID: 29440429
PMC: PMC5834676
Other: Epub 2018
 Degree: -

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Project name : -
Grant ID : 91515956
Funding program : -
Funding organization : German Academic Exchange Service
Project name : The Human Brain Project / HBP
Grant ID : 604102
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Neurobiologie motivierten Verhaltens / SFB 779
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proceedings of the National Academy of Sciences of the USA
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 115 (9) Sequence Number: - Start / End Page: 2228 - 2233 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230