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  Expression of active human factor VIII from recombinant DNA clones

Wood, W. I., Capon, D. J., Simonsen, C. C., Eaton, D. L., Gitschier, J., Keyt, B., et al. (1984). Expression of active human factor VIII from recombinant DNA clones. Nature, 312(5992), 330-337. doi:10.1038/312330a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-D4DA-B Version Permalink: https://hdl.handle.net/21.11116/0000-0000-D4DB-A
Genre: Journal Article

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Nature_312_1984_330.pdf (Any fulltext), 1017KB
 
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 Creators:
Wood, William I., Author
Capon, Daniel J., Author
Simonsen, Christian C., Author
Eaton, Dan L., Author
Gitschier, Jane, Author
Keyt, Bruce, Author
Seeburg, Peter H.1, Author           
Smith, Douglas H., Author
Hollingshead, Philip, Author
Wion, Karen L., Author
Delwart, Eric, Author
Tuddenham, Edward G. D., Author
Vehar, Gordon A., Author
Lawn, Richard M., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: DNA clones encoding the complete 2,351 amino acid sequence for human factor VIII have been isolated and used to produce biologically active factor VIII in cultured mammalian cells. The recombinant protein corrects the clotting time of plasma from haemophiliacs and has many of the biochemical and immunological characteristics of serum-derived factor VIII.

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Language(s): eng - English
 Dates: 1984-08-091984-09-271984
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/312330a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/6438526
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 312 (5992) Sequence Number: - Start / End Page: 330 - 337 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238