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  Distant from input: Evidence of regions within the default mode network supporting perceptually-decoupled and conceptually-guided cognition

Murphy, C., Jefferies, E., Rueschemeyer, S.-A., Sormaz, M., Wang, H.-t., Margulies, D. S., et al. (2018). Distant from input: Evidence of regions within the default mode network supporting perceptually-decoupled and conceptually-guided cognition. NeuroImage, 171, 393-401. doi:10.1016/j.neuroimage.2018.01.017.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-D5E8-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A4A0-E
Genre: Journal Article

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 Creators:
Murphy, Charlotte1, Author
Jefferies, Elizabeth1, Author
Rueschemeyer, Shirley-Ann1, Author
Sormaz, Mladen1, Author
Wang, Hao-ting1, Author
Margulies, Daniel S.2, Author              
Smallwood, Jonathan1, Author
Affiliations:
1York Neuroimaging Centre, University of York, United Kingdom, ou_persistent22              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              

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Free keywords: Transmodal cortex; Default mode network; Semantic; Conceptual processing; Stimulus independence
 Abstract: The default mode network supports a variety of mental operations such as semantic processing, episodic memory retrieval, mental time travel and mind-wandering, yet the commonalities between these functions remains unclear. One possibility is that this system supports cognition that is independent of the immediate environment; alternatively or additionally, it might support higher-order conceptual representations that draw together multiple features. We tested these accounts using a novel paradigm that separately manipulated the availability of perceptual information to guide decision-making and the representational complexity of this information. Using task based imaging we established regions that respond when cognition combines both stimulus independence with multi-modal information. These included left and right angular gyri and the left middle temporal gyrus. Although these sites were within the default mode network, they showed a stronger response to demanding memory judgements than to an easier perceptual task, contrary to the view that they support automatic aspects of cognition. In a subsequent analysis, we showed that these regions were located at the extreme end of a macroscale gradient, which describes gradual transitions from sensorimotor to transmodal cortex. This shift in the focus of neural activity towards transmodal, default mode, regions might reflect a process of where the functional distance from specific sensory enables conceptually rich and detailed cognitive states to be generated in the absence of input.

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Language(s): eng - English
 Dates: 2018-01-092017-06-222018-01-092018-01-122018-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.01.017
PMID: 29339310
PMC: PMC5883322
Other: Epub 2018
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Project name : -
Grant ID : BB/J006963/1
Funding program : -
Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)
Project name : Wedding bells or bedding wells? Lexical and semantic influences on phoneme binding / SEMBIND
Grant ID : 283530
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : The role of DREAM in synaptic dysfunction in Alzheimer's disease / DREAM IN AD
Grant ID : 303701
Funding program : Funding Programme 7
Funding organization : European Commission (EC)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 171 Sequence Number: - Start / End Page: 393 - 401 Identifier: ISSN: 1053-8119
CoNE: /journals/resource/954922650166