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  Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H., & Goeddel, D. V. (1983). Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature, 302(5903), 33-37. doi:10.1038/302033a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-DB4A-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-DB4B-6
Genre: Journal Article

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Nature_302_1983_33.pdf (Any fulltext), 663KB
 
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 Creators:
Capon, Daniel J., Author
Chen, Ellson Y., Author
Levinson, Arthur D., Author
Seeburg, Peter H.1, Author           
Goeddel, David V., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least four exons, and that only a single point mutation residing within the first exon distinguishes the coding region of both alleles of the normal gene from their activated counterpart. Both versions of the gene encode a protein which is predicted to differ from the corresponding viral gene product at three amino acid residues, one of which was previously shown to represent the major site of phosphorylation of the viral polypeptide.

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Language(s): eng - English
 Dates: 1982-12-231983-01-141983-03-031983-03-03
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/302033a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/6298635
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 302 (5903) Sequence Number: - Start / End Page: 33 - 37 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238