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  AP-2 epsilon Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells

Jain, S., Glubrecht, D. D., Germain, D. R., Moser, M., & Godbout, R. (2018). AP-2 epsilon Expression in Developing Retina: Contributing to the Molecular Diversity of Amacrine Cells. Scientific Reports, 8: 3386. doi:10.1038/s41598-018-21822-y.

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 Creators:
Jain, Saket1, Author
Glubrecht, Darryl D.1, Author
Germain, Devon R.1, Author
Moser, Markus2, Author              
Godbout, Roseline1, Author
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1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: TRANSCRIPTION FACTOR AP-2; DEVELOPING CHICK RETINA; DNA-BINDING; MOUSE EMBRYOGENESIS; FATE DETERMINATION; VERTEBRATE RETINA; AUTONOMOUS ROLES; FACTOR AP-2-BETA; GENE-EXPRESSION; LENS VESICLEScience & Technology - Other Topics;
 Abstract: AP-2 transcription factors play important roles in the regulation of gene expression during development. Four of the five members of the AP-2 family (AP-2 alpha, AP-2 beta, AP-2 gamma and AP-2 delta) have previously been shown to be expressed in developing retina. Mouse knockouts have revealed roles for AP-2 alpha, AP-2 beta and AP-2 delta in retinal cell specification and function. Here, we show that the fifth member of the AP-2 family, AP-2 epsilon, is also expressed in amacrine cells in developing mammalian and chicken retina. Our data indicate that there are considerably fewer AP-2 epsilon-positive cells in the developing mouse retina compared to AP-2 alpha, AP-2 beta and AP-2 gamma-positive cells, suggesting a specialized role for AP-2 epsilon in a subset of amacrine cells. AP-2e, which is restricted to the GABAergic amacrine lineage, is most commonly co-expressed with AP-2 alpha and AP-2 beta, especially at early stages of retinal development. Coexpression of AP-2 epsilon and AP-2 gamma increases with differentiation. Analysis of previously published Drop-seq data from single retinal cells supports co-expression of multiple AP-2s in the same cell. Since AP-2s bind to their target sequences as either homodimers or heterodimers, our work suggests spatially-and temporally-coordinated roles for combinations of AP-2 transcription factors in amacrine cells during retinal development.

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Language(s): eng - English
 Dates: 2018
 Publication Status: Published online
 Pages: 13
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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 3386 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322