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  Palladium-catalyzed carbon-sulfur or carbon-phosphorus bond metathesis by reversible arylation

Lian, Z., Bhawal, B. N., Yu, P., & Morandi, B. (2017). Palladium-catalyzed carbon-sulfur or carbon-phosphorus bond metathesis by reversible arylation. Science, 356(6342), 1059-1063. doi:10.1126/science.aam9041.

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Genre: Journal Article

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 Creators:
Lian, Zhong1, Author              
Bhawal, Benjamin N.1, Author              
Yu, Peng1, Author
Morandi, Bill1, Author              
Affiliations:
1Research Group Morandi, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_2040309              

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 Abstract: Compounds bearing aryl-sulfur and aryl-phosphorus bonds have found numerous applications in drug development, organic materials, polymer science, and homogeneous catalysis. We describe palladium-catalyzed metathesis reactions of both compound classes, each of which proceeds through a reversible arylation manifold. The synthetic power and immediate utility of this approach are demonstrated in several applications that would be challenging to achieve by means of traditional cross-coupling methods. The C(sp2)–S bond metathesis protocol was used in the depolymerization of a commercial thermoplastic polymer and in the late-stage derivatization of a drug. The C(sp2)–P variant led to the convenient preparation of a variety of phosphorus heterocycles, including a potential chiral ligand and fluorescent organic materials, via a ring-closing transformation.

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Language(s): eng - English
 Dates: 2017-02-022017-05-152017-06-09
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.aam9041
 Degree: -

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Title: Science
Source Genre: Journal
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Affiliations:
Publ. Info: American Association for the Advancement of Science
Pages: - Volume / Issue: 356 (6342) Sequence Number: - Start / End Page: 1059 - 1063 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1