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  Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

Capon, D. J., Seeburg, P. H., McGrath, J., Hayflick, J. S., Edman, U., Levinson, A. D., et al. (1983). Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature, 304(5926), 507-513. doi:10.1038/304507a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-E752-F Version Permalink: https://hdl.handle.net/21.11116/0000-0000-E753-E
Genre: Journal Article

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Nature_304_1983_507.pdf (Any fulltext), 851KB
 
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https://www.nature.com/articles/304507a0.pdf (Any fulltext)
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https://doi.org/10.1038/304507a0 (Any fulltext)
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 Creators:
Capon, Daniel J., Author
Seeburg, Peter H.1, Author           
McGrath, John, Author
Hayflick, Joel S., Author
Edman, Ursula, Author
Levinson, Arthur D., Author
Goeddel, David V., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses sequences from a fourth coding exon distinct from that of its viral counterpart; and that at least one cell line is functionally homozygous for the activated gene.

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Language(s): eng - English
 Dates: 1982-12-131983-02-221983-08-111983-08-11
 Publication Status: Issued
 Pages: 7
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/304507a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/6308467
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 304 (5926) Sequence Number: - Start / End Page: 507 - 513 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238