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  White matter microstructural variability mediates the relation between obesity and cognition in healthy adults

Zhang, R., Beyer, F., Lampe, L., Luck, T., Riedel-Heller, S. G., Loeffler, M., et al. (2018). White matter microstructural variability mediates the relation between obesity and cognition in healthy adults. NeuroImage, 172, 239-249. doi:10.1016/j.neuroimage.2018.01.028.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0000-E7C2-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9782-F
Genre: Journal Article

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 Creators:
Zhang, Rui1, 2, Author              
Beyer, Frauke1, 2, Author              
Lampe, Leonie1, 3, Author              
Luck, Tobias3, 4, Author
Riedel-Heller, Steffi G.3, 4, Author
Loeffler, Markus3, 5, Author
Schroeter, Matthias L.1, 6, Author              
Stumvoll, Michael2, 7, Author
Villringer, Arno1, 2, 3, 6, Author              
Witte, Veronica1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
4Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
5Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
6Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
7Clinic for Endocrinology and Nephrology, University Hospital Leipzig, Germany, ou_persistent22              

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Free keywords: DTI; Fractional anisotropy; Executive functions; Processing speed
 Abstract: Obesity has been linked with structural and functional brain changes. However, the impact of obesity on brain and cognition in aging remains debatable, especially for white matter. We therefore aimed to determine the effects of obesity on white matter microstructure and potential implications for cognition in a well-characterized large cohort of healthy adults. In total, 1255 participants (50% females, 19–80 years, BMI 16.8–50.2 kg/m2) with diffusion-weighted magnetic resonance imaging at 3T were analysed. Tract-based spatial statistics (TBSS) probed whether body mass index (BMI) and waist-to-hip ratio (WHR) were related to fractional anisotropy (FA). We conducted partial correlations and mediation analyses to explore whether obesity or regional FA were related to cognitive performance. Analyses were adjusted for demographic, genetic, and obesity-associated confounders. Results showed that higher BMI and higher WHR were associated with lower FA in multiple white matter tracts (p < 0.05, FWE-corrected). Mediation analyses provided evidence for indirect negative effects of higher BMI and higher WHR on executive functions and processing speed through lower FA in fiber tracts connecting (pre)frontal, visual, and associative areas (indirect paths, |ß| ≥ 0.01; 99% |CI| > 0). This large cross-sectional study showed that obesity is correlated with lower FA in multiple white matter tracts in otherwise healthy adults, independent of confounders. Moreover, although effect sizes were small, mediation results indicated that visceral obesity was linked to poorer executive functions and lower processing speed through lower FA in callosal and associative fiber tracts. Longitudinal studies are needed to support this hypothesis.

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Language(s): eng - English
 Dates: 2017-12-052017-09-142018-01-122018-02-032018-05-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.01.028
PMID: 29378320
Other: Epub 2018
 Degree: -

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Project name : -
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Funding organization : European Union (EU)
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Grant ID : -
Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Free State of Saxony
Project name : -
Grant ID : 713-241202 ; 14505/2470 ; 14575/2470
Funding program : -
Funding organization : LIFE–Leipzig Research Center for Civilization Diseases, University of Leipzig
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : WI 3342/3-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: NeuroImage
Source Genre: Journal
 Creator(s):
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 172 Sequence Number: - Start / End Page: 239 - 249 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166