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  De novo evolved interference competition promotes the spread of biofilm defectors

Martin, M., Dragoš, A., Hölscher, T., Maróti, G., Bálint, B., Westermann, M., et al. (2017). De novo evolved interference competition promotes the spread of biofilm defectors. Nature Communications, 8: 15127. doi:10.1038/ncomms15127.

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http://dx.doi.org/10.1038/ncomms15127 (Publisher version)
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 Creators:
Martin, Marivic, Author
Dragoš, Anna, Author
Hölscher, Theresa1, Author           
Maróti, Gergely, Author
Bálint, Balázs, Author
Westermann, Martin, Author
Kovács, Ákos T., Author
Affiliations:
1IMPRS on Ecological Interactions, MPI for Chemical Ecology, Max Planck Society, ou_421900              

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 Abstract: Biofilms are social entities where bacteria live in tightly packed agglomerations, surrounded by self-secreted exopolymers. Since production of exopolymers is costly and potentially exploitable by non-producers, mechanisms that prevent invasion of non-producing mutants are hypothesized. Here we study long-term dynamics and evolution in Bacillus subtilis biofilm populations consisting of wild-type (WT) matrix producers and mutant non-producers. We show that non-producers initially fail to incorporate into biofilms formed by the WTcells, resulting in 100-fold lower final frequency compared to the WT. However, this is modulated in a long-term scenario, as non-producers evolve the ability to better incorporate into biofilms, thereby slightly decreasing the productivity of the whole population. Detailed molecular analysis reveals that the unexpected shift in the initially stable biofilm is coupled with newly evolved phage-mediated interference competition. Our work therefore demonstrates how collective behaviour can be disrupted as a result of rapid adaptation through mobile genetic elements.

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 Dates: 2017-03-022017-05-022017
 Publication Status: Published in print
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 Identifiers: Other: IMPRS089
DOI: 10.1038/ncomms15127
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 15127 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723