English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Peptide sharing between viruses and DLX proteins: A potential cross-reactivity pathway to neuropsychiatric disorders

Lucchese, G., & Stahl, B. (2018). Peptide sharing between viruses and DLX proteins: A potential cross-reactivity pathway to neuropsychiatric disorders. Frontiers in Neuroscience, 12: 150. doi:10.3389/fnins.2018.00150.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0000-F01E-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4D67-2
Genre: Journal Article

Files

show Files
hide Files
:
Lucchese_Stahl_2017.pdf (Publisher version), 969KB
Name:
Lucchese_Stahl_2017.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Lucchese, Guglielmo1, 2, Author
Stahl, Benjamin2, 3, 4, 5, Author              
Affiliations:
1Brain Language Laboratory, Department of Philosophy and Humanities, FU Berlin, Germany, ou_persistent22              
2Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
3Department of Neurology, Charité University Medicine Berlin, Berlin, Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Psychologische Hochschule Berlin, Germany, ou_persistent22              

Content

show
hide
Free keywords: Viral infections; Neuropsychiatric diseases; Language disorders; Fetal and adult neurogenesis; DLX proteins; Peptide sharing; Cross-reactivity; Autoimmunity
 Abstract: The present study seeks to determine potential associations between viral infections and neuropsychiatric diseases. To address this issue, we investigated the peptide commonalities between viruses that have been related to psychiatric and neurological disorders—such as rubella, human immunodeficiency virus, and herpesviruses—and human distal-less homeobox (DLX) proteins expressed in developing brain—namely, DLX1, DLX2, DLX5, and DLX6. Peptide matching analyses revealed a high degree of pentapeptide sharing. From an immunological perspective, this overlap is relevant because pentapeptides are endowed with immunogenicity and antigenicity—that is, they are immune determinants. Moreover, infection-induced immune cross-reactions might have functional, spatial, and temporal implications related to the functions and expression patterns of DLX1 and DLX5 in the fetal and adult human brain. In sum, our data support the hypothesis that viral infections may be linked to neuropsychiatric diseases through autoimmune cross-reactions caused by molecular mimicry between viral proteins and brain-specific DLX self-antigens.

Details

show
hide
Language(s): eng - English
 Dates: 2017-06-242018-02-262018-03-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fnins.2018.00150
PMID: 29618965
PMC: PMC5871705
Other: eCollection 2018
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : OpenAccess Publication Funds
Funding organization : Freie Universität Berlin

Source 1

show
hide
Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 150 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548