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  The primary structure and genetic organization of the bovine papillomavirus type 1 genome

Chen, E. Y., Howley, P. M., Levinson, A. D., & Seeburg, P. H. (1982). The primary structure and genetic organization of the bovine papillomavirus type 1 genome. Nature, 299(5883), 529-534. doi:10.1038/299529a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-F41B-F Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F41C-E
Genre: Journal Article

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Nature_299_1982_529.pdf (Any fulltext), 660KB
 
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 Creators:
Chen, Ellson Y., Author
Howley, Peter M., Author
Levinson, Arthur D., Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The complete nucleotide sequence of the doubt-stranded circular DNA of bovine papillomavirus type 1 (BPV-1) was determined. Analysis of this sequence in conjunction with known transcriptional data for the virus provides a basis of determining the organization of the papillomavirus genome. All the major open reading frames are located on the same DNA strand. The region transcribed in BPV-transformed cells contains open frames in all three translational frames whereas the region transcribed in productively infected bovine fibropapillomas is characterized by two large open reading frames partitioned by a single translational stop codon. The localization of sequences diagnostic of promoters and polyadenylation sites suggests that splicing is involved in the biosynthesis of the viral mRNAs. A sequence comparison indicates the genome organization of the bovine papillomavirus and that of the members of the simian virus 40-polyomavirus subgroup to be distinct, suggesting that these two groups of viruses are evolutionarily unrelated.

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Language(s): eng - English
 Dates: 1982-04-141982-06-301982-10-07
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/299529a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/6289124
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 299 (5883) Sequence Number: - Start / End Page: 529 - 534 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238