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  Microstructural imaging of human neocortex in vivo

Edwards, L., Kirilina, E., Mohammadi, S., & Weiskopf, N. (2018). Microstructural imaging of human neocortex in vivo. NeuroImage, 182, 184-206. doi:10.1016/j.neuroimage.2018.02.055.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0001-182C-4 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0005-4ACF-0
資料種別: 学術論文

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manuscript.pdf (プレプリント), 8MB
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Edwards_2018.pdf
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作成者

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 作成者:
Edwards, Luke1, 著者           
Kirilina, Evgeniya1, 2, 著者           
Mohammadi , Siawoosh1, 3, 著者
Weiskopf, Nikolaus1, 著者           
所属:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
3Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              

内容説明

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キーワード: hMRI; Quantitative; High resolution
 要旨: The neocortex of the human brain is the seat of higher brain function. Modern imaging techniques, chief among them magnetic resonance imaging (MRI), allow non-invasive imaging of this important structure.

Knowledge of the microstructure of the neocortex has classically come from post-mortem histological studies of human tissue, and extrapolations from invasive animal studies. From these studies, we know that the scale of important neocortical structure spans six orders of magnitude, ranging from the size of axonal diameters (microns), to the size of cortical areas responsible for integrating sensory information (centimetres). MRI presents an opportunity to move beyond classical methods, because MRI is non-invasive and MRI contrast is sensitive to neocortical microstructure over all these length scales. MRI thus allows inferences to be made about neocortical microstructure in vivo, i.e. MRI-based in vivo histology.

We review recent literature that has applied and developed MRI-based in vivo histology to probe the microstructure of the human neocortex, focusing specifically on myelin, iron, and neuronal fibre mapping. We find that applications such as cortical parcellation (using
maps as proxies for myelin content) and investigation of cortical iron deposition with age (using

maps) are already contributing to the frontiers of knowledge in neuroscience. Neuronal fibre mapping in the cortex remains challenging in vivo, but recent improvements in diffusion MRI hold promise for exciting applications in the near future. The literature also suggests that utilising multiple complementary quantitative MRI maps could increase the specificity of inferences about neocortical microstructure relative to contemporary techniques, but that further investment in modelling is required to appropriately combine the maps.

In vivo histology of human neocortical microstructure is undergoing rapid development. Future developments will improve its specificity, sensitivity, and clinical applicability, granting an ever greater ability to investigate neuroscientific and clinical questions about the human neocortex.

資料詳細

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言語: eng - English
 日付: 2018-02-132017-10-092018-02-262018-03-262018-11-15
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.neuroimage.2018.02.055
PMID: 29588229
その他: Epub 2018
 学位: -

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Project information

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Project name : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : FP7/2007-2013 (ERC-2013-CoG)
Funding organization : European Commission (EC)
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical prof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020 (H2020-PHC-2014-2015)
Funding organization : European Union (EU)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : NEURON-Verbund hMRTofScl: Entschlüsselung der pathophysiologischen Prozesse induziert durch eine Querschnittslähmung: Anwendung von MRT basierter in vivo und ex vivo Histologie / Era-Net NEURON
Grant ID : 01W1711B
Funding program : ERA-NET NEURON Call (ERA-NET NEURON JTC2016)
Funding organization : German Ministry for Education and Research (BMBF)
Project name : Taking imaging into the therapeutc domain: Self- regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Funding program : Funding Programme 7 (FP7- HEALTH-2013-INNOVATION-1)
Funding organization : European Commission (EC)
Project name : Mesoscopic characterization of human white-matter: A computational in-vivo MRI framework
Grant ID : 658589
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : MO 2397/4-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

出版物 1

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出版物名: NeuroImage
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Orlando, FL : Academic Press
ページ: - 巻号: 182 通巻号: - 開始・終了ページ: 184 - 206 識別子（ISBN, ISSN, DOIなど）: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166