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  SAMHD1 prevents autoimmunity by maintaining genome stability.

Kretschmer, S., Wolf, C., König, N., Staroske, W., Guck, J., Häusler, M., et al. (2015). SAMHD1 prevents autoimmunity by maintaining genome stability. Annals of the Rheumatic Diseases, 74(3): e17.

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 Creators:
Kretschmer, Stefanie, Author
Wolf, Christine, Author
König, Nadja, Author
Staroske, Wolfgang1, Author
Guck, Jochen1, Author
Häusler, Martin, Author
Luksch, H, Author
Nguyen, Laura A, Author
Kim, Baek, Author
Alexopoulou, Dimitra, Author
Dahl, Andreas1, Author
Rapp, Alexander, Author
Cardoso, M Cristina, Author
Shevchenko, Anna2, Author           
Lee-Kirsch, Min Ae, Author
Affiliations:
1Max Planck Society, ou_persistent13              
2Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi-Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity with systemic lupus erythematosus, including activation of antiviral type 1 interferon (IFN). To further define the pathomechanisms underlying autoimmunity in AGS due to SAMHD1 mutations, we investigated the physiological properties of SAMHD1.

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 Dates: 2015
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: eDoc: 718054
Other: 6135
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Title: Annals of the Rheumatic Diseases
Source Genre: Journal
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Pages: - Volume / Issue: 74 (3) Sequence Number: e17 Start / End Page: - Identifier: -