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  Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death.

Neumann, K., Castiñeiras-Vilariño, M., Höckendorf, U., Hannesschläger, N., Lemeer, S., Kupka, D., et al. (2014). Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death. Immunity, 40(3), 389-399.

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 Creators:
Neumann, Konstantin, Author
Castiñeiras-Vilariño, Mercedes, Author
Höckendorf, Ulrike, Author
Hannesschläger, Nicole, Author
Lemeer, Simone, Author
Kupka, Danny, Author
Meyermann, Svenia, Author
Lech, Maciej, Author
Anders, Hans-Joachim, Author
Kuster, Bernhard, Author
Busch, Dirk H, Author
Gewies, Andreas, Author
Naumann, Ronald1, Author           
Groß, Olaf, Author
Ruland, Jurgen2, Author
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              
2Max Planck Society, ou_persistent13              

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 Abstract: Recognition of cell death by the innate immune system triggers inflammatory responses. However, how these reactions are regulated is not well understood. Here, we identify the inhibitory C-type lectin receptor Clec12a as a specific receptor for dead cells. Both human and mouse Clec12a could physically sense uric acid crystals (monosodium urate, MSU), which are key danger signals for cell-death-induced immunity. Clec12a inhibited inflammatory responses to MSU in vitro, and Clec12a-deficient mice exhibited hyperinflammatory responses after being challenged with MSU or necrotic cells and after radiation-induced thymocyte killing in vivo. Thus, we identified a negative regulatory MSU receptor that controls noninfectious inflammation in response to cell death that has implications for autoimmunity and inflammatory disease.

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 Dates: 2014
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: eDoc: 705772
Other: 5677
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Title: Immunity
Source Genre: Journal
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Pages: - Volume / Issue: 40 (3) Sequence Number: - Start / End Page: 389 - 399 Identifier: -