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  Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells.

Zietara, N., Lyszkiewicz, M., Witzlau, K., Naumann, R., Hurwitz, R., Langemeier, J., et al. (2013). Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. Proceedings of the National Academy of Sciences of the United States of America, 110(18), 7407-7412.

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Datensatz-Permalink: http://hdl.handle.net/21.11116/0000-0001-06B0-1 Versions-Permalink: http://hdl.handle.net/21.11116/0000-0001-06B1-0
Genre: Zeitschriftenartikel

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 Urheber:
Zietara, Natalia, Autor
Lyszkiewicz, Marcin1, Autor
Witzlau, Katrin, Autor
Naumann, Ronald2, Autor              
Hurwitz, Robert, Autor
Langemeier, Jörg, Autor
Bohne, Jens, Autor
Sandrock, Inga, Autor
Ballmaier, Matthias, Autor
Weiss, Siegfried, Autor
Prinz, Immo1, Autor
Krueger, Andreas1, Autor
Affiliations:
1Max Planck Society, ou_persistent13              
2Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction in iNKT cell numbers in thymus as well as in the periphery. Increased concentrations of agonist ligand rescued iNKT cell development in miR-181a/b-1(-/-) mice. Our results define a critical role of miR-181a/b-1 in early iNKT cell development and show that miR-181a/b-1 sets a TCR signaling threshold for agonist selection.

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 Datum: 2013
 Publikationsstatus: Im Druck publiziert
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Interne Begutachtung
 Identifikatoren: eDoc: 688490
Anderer: 5641
 Art des Abschluß: -

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Titel: Proceedings of the National Academy of Sciences of the United States of America
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 110 (18) Artikelnummer: - Start- / Endseite: 7407 - 7412 Identifikator: -