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  RhoD participates in the regulation of cell-cycle progression and centrosome duplication.

Kyrkou, A., Soufi, M., Bahtz, R., Ferguson, C., Bai, M., Parton, R. G., et al. (2013). RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene, 32(14), 1831-1842.

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Kyrkou, A, Author
Soufi, M, Author
Bahtz, R, Author
Ferguson, Charles1, Author           
Bai, M, Author
Parton, Robert G.2, Author
Hoffmann, I, Author
Zerial, Marino1, Author           
Fotsis, Theodore, Author
Murphy, C, Author
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              
2Max Planck Society, ou_persistent13              

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 Abstract: We have previously identified a Rho protein, RhoD, which localizes to the plasma membrane and the early endocytic compartment. Here, we show that a GTPase-deficient mutant of RhoD, RhoDG26V, causes hyperplasia and perturbed differentiation of the epidermis, when targeted to the skin of transgenic mice. In vitro, gain-of-function and loss-of-function approaches revealed that RhoD is involved in the regulation of G1/S-phase progression and causes overduplication of centrosomes. Centriole overduplication assays in aphidicolin-arrested p53-deficient U2OS cells, in which the cell and the centrosome cycles are uncoupled, revealed that the effects of RhoD and its mutants on centrosome duplication and cell cycle are independent. Enhancement of G1/S-phase progression was mediated via Diaph1, a novel effector of RhoD, which we have identified using a two-hybrid screen. These results indicate that RhoD participates in the regulation of cell-cycle progression and centrosome duplication.Oncogene advance online publication, 4 June 2012; doi:10.1038/onc.2012.195.

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 Dates: 2013
 Publication Status: Issued
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 Identifiers: eDoc: 688501
Other: 4889
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Title: Oncogene
Source Genre: Journal
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Pages: - Volume / Issue: 32 (14) Sequence Number: - Start / End Page: 1831 - 1842 Identifier: -