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  Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave.

Haas, J., Ravens, S., Düber, S., Sandrock, I., Oberdörfer, L., Kashani, E., et al. (2012). Development of Interleukin-17-Producing γδ T Cells Is Restricted to a Functional Embryonic Wave. Immunity, 37(1), 48-59.

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 Creators:
Haas, Jens, Author
Ravens, Sarina, Author
Düber, Sandra, Author
Sandrock, Inga, Author
Oberdörfer, Linda, Author
Kashani, Elham, Author
Chennupati, Vijaykumar, Author
Föhse, Lisa, Author
Naumann, Ronald1, Author           
Weiss, Siegfried, Author
Krueger, Andreas2, Author
Förster, Reinhold, Author
Prinz, Immo2, Author
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              
2Max Planck Society, ou_persistent13              

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 Abstract: γδ T cells are an important innate source of interleukin-17 (IL-17). In contrast to T helper 17 (Th17) cell differentiation, which occurs in the periphery, IL-17-producing γδ T cells (γδT17 cells) are probably committed during thymic development. To study when γδT17 cells arise during ontogeny, we used TcrdH2BeGFP reporter mice to monitor T cell receptor (TCR) rearrangement and IL-17 production in the embryonic thymus. We observed that several populations such as innate lymphoid cells and early T cell precursors were able to produce IL-17 prior to (and thus independent of) TCR recombination. γδT17 cells were absent after transplantation of IL-17-sufficient bone marrow into mice lacking both Il17a and Il17f. Also, γδT17 cells were not generated after genetic restoration of defective Rag1 function in adult mice. Together, these data suggested that these cells developed exclusively before birth and subsequently persisted in adult mice as self-renewing, long-lived cells.

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 Dates: 2012
 Publication Status: Issued
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 Identifiers: eDoc: 645261
Other: 4912
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Title: Immunity
Source Genre: Journal
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Pages: - Volume / Issue: 37 (1) Sequence Number: - Start / End Page: 48 - 59 Identifier: -