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  Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility.

Goudarzi, M., Banisch, T. U., Mobin, M. B., Maghelli, N., Tarbashevich, K., Strate, I., et al. (2012). Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell, 23(1), 210-218.

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 Creators:
Goudarzi, Mehdi, Author
Banisch, Torsten U, Author
Mobin, Mehrpouya B, Author
Maghelli, Nicola1, Author           
Tarbashevich, Katsiaryna, Author
Strate, Ina, Author
Berg, Jana van den, Author
Blaser, Heiko, Author
Bandemer, Sabine, Author
Paluch, Ewa1, Author           
Bakkers, Jeroen, Author
Tolic-Norrelykke, Iva M.1, Author           
Raz, Erez, Author
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: Single-cell migration is a key process in development, homeostasis, and disease. Nevertheless, the control over basic cellular mechanisms directing cells into motile behavior in vivo is largely unknown. Here, we report on the identification of a minimal set of parameters the regulation of which confers proper morphology and cell motility. Zebrafish primordial germ cells rendered immotile by knockdown of Dead end, a negative regulator of miRNA function, were used as a platform for identifying processes restoring motility. We have defined myosin contractility, cell adhesion, and cortex properties as factors whose proper regulation is sufficient for restoring cell migration of this cell type. Tight control over the level of these cellular features, achieved through a balance between miRNA-430 function and the action of the RNA-binding protein Dead end, effectively transforms immotile primordial germ cells into polarized cells that actively migrate relative to cells in their environment.

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 Dates: 2012
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: eDoc: 645273
Other: 4849
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Title: Developmental Cell
Source Genre: Journal
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Pages: - Volume / Issue: 23 (1) Sequence Number: - Start / End Page: 210 - 218 Identifier: -