Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA 
replication

Mouysset, Julien; Deichsel, Alexandra; Moser, Sandra; Hoege, Carsten; Hyman, Anthony A; Gartner, Anton; Hoppe, Thorsten

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Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication

Mouysset, J., Deichsel, A., Moser, S., Hoege, C., Hyman, A. A., Gartner, A., et al. (2008). Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proceedings of the National Academy of Sciences of the United States of America, 105(35), 12879-12884.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-0DF2-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-0DF3-F

Genre: Journal Article

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Creators:
Mouysset, Julien, Author
Deichsel, Alexandra, Author
Moser, Sandra, Author
Hoege, Carsten¹, Author
Hyman, Anthony A¹, Author
Gartner, Anton, Author
Hoppe, Thorsten, Author

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1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692

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Abstract: Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cell cycle control. Our analysis of the CDC-48(UFD-1/NPL-4) complex identified a general role in S phase progression of mitotic cells essential for embryonic cell division and germline development of adult worms. These developmental defects result from activation of the DNA replication checkpoint caused by replication stress. Similar to loss of replication licensing factors, DNA content is strongly reduced in worms depleted for CDC-48, UFD-1, and NPL-4. In addition, these worms show decreased DNA synthesis and hypersensitivity toward replication blocking agents. Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability.

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Dates: Date issued: 2008

Publication Status: Issued

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Identifiers: eDoc: 414322
Other: 984

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Title: Proceedings of the National Academy of Sciences of the United States of America

Source Genre: Journal

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Pages: - Volume / Issue: 105 (35) Sequence Number: - Start / End Page: 12879 - 12884 Identifier: -