English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets

Jabs, N., Franklin, I., Brenner, M. B., Gromada, J., Ferrara, N., Wollheim, C. B., et al. (2008). Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets. Experimental and Clinical Endocrinology & Diabetes, 116(Suppl. 1), S46-S49.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Jabs, N1, Author           
Franklin, I, Author
Brenner, M B, Author
Gromada, J, Author
Ferrara, N, Author
Wollheim, C B, Author
Lammert, E1, Author           
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

Content

show
hide
Free keywords: -
 Abstract: Mice, deficient for vascular endothelial growth factor VEGF-A in pancreatic islets, have reduced insulin gene expression levels and an impaired glucose tolerance. Here, we investigated whether VEGF-A was required for physiological glucose-stimulated insulin secretion and insulin content. We performed in situ pancreas perfusions and islet perifusions on mice lacking VEGF-A in the pancreatic epithelium in order to study their ability to secrete insulin in response to glucose. We identified insulin secretion defects in the pancreata of VEGF-A deficient mice, including a delayed and blunted response to glucose. Islet perifusion experiments revealed a missing first phase and weaker second phase of insulin secretion, in two of three VEGF-A deficient mice. On average, insulin content in VEGF-A deficient islets was significantly reduced when compared with control islets. We conclude that VEGF-A is required in pancreatic islets for normal glucose-stimulated insulin secretion and physiological insulin content. Thus, VEGF-A is a key factor for pancreatic islet function.

Details

show
hide
Language(s):
 Dates: 2008
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 414433
Other: 1194
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Experimental and Clinical Endocrinology & Diabetes
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 116 (Suppl. 1) Sequence Number: - Start / End Page: S46 - S49 Identifier: -