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Schlagwörter:
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Zusammenfassung:
In the developing fly wing, secreted morphogens such as Decapentaplegic (Dpp) and Wingless (Wg)
form gradients of concentration providing positional information. Dpp forms a longer-range
gradient than Wg. To understand how the range is controlled, we measured the four key kinetic
parameters governing morphogen spreading: the production rate, the effective diffusion
coefficient, the degradation rate, and the immobile fraction. The four parameters had different
values for Dpp versus Wg. In addition, Dynamin-dependent endocytosis was required for spreading
of Dpp, but not Wg. Thus, the cellular mechanisms of Dpp and Wingless spreading are different:
Dpp spreading requires endocytic, intracellular trafficking.
