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  The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion

Hardt, S. v. d., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C.-P., et al. (2007). The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion. Current Biology, 17(6), 475-487.

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Hardt, Sophia von der, Autor
Bakkers, Jeroen, Autor
Inbal, Adi, Autor
Carvalho, Lara1, Autor           
Solnica-Krezel, Lilianna, Autor
Heisenberg, Carl-Philipp1, Autor           
Hammerschmidt, Matthias, Autor
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: Background: Bone morphogenetic proteins (Bmps) are required for the specification of ventrolateral cell fates during embryonic dorsoventral patterning and for proper convergence and extension gastrulation movements, but the mechanisms underlying the latter role remained elusive. Results: Via bead implantations, we show that the Bmp gradient determines the direction of lateral mesodermal cell migration during dorsal convergence in the zebrafish gastrula. This effect is independent of its role during dorsoventral patterning and of noncanonical Wnt signaling. However, it requires Bmp signal transduction through Alk8 and Smad5 to negatively regulate Ca2+/ Cadherin-dependent cell-cell adhesiveness. In vivo, converging mesodermal cells form lamellipodia that attach to adjacent cells. Bmp signaling diminishes the Cadherin-dependent stability of such contact points, thereby abrogating subsequent cell displacement during lamellipodial retraction. Conclusions: We propose that the ventral-to-dorsal Bmp gradient has an instructive role to establish a reverse gradient of cell-cell adhesiveness, thereby defining different migratory zones and directing lamellipodia- driven cell migrations during dorsal convergence in lateral regions of the zebrafish gastrula.

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 Datum: 2007
 Publikationsstatus: Erschienen
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 Identifikatoren: eDoc: 348507
Anderer: 943
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Titel: Current Biology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 17 (6) Artikelnummer: - Start- / Endseite: 475 - 487 Identifikator: -