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  The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos

Schonegg, S., Constantinescu, A. T., Hoege, C., & Hyman, A. A. (2007). The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Proceedings of the National Academy of Sciences, USA, 104(38), 14976-14981.

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 Creators:
Schonegg, Stephanie1, Author           
Constantinescu, Alexandru T.1, Author           
Hoege, Carsten1, Author           
Hyman, Anthony A.1, Author           
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: Caenorhabditis elegans embryos establish cortical domains of PAR proteins of reproducible size before asymmetric cell division. The ways in which the size of these domains is set remain unknown. Here we identify the GTPase-activating proteins (GAPs) RGA-3 and RGA-4, which regulate the activity of the small GTPase RHO-1. rga-3/4(RNAi) embryos have a hypercontractile cortex, and the initial relative size of their anterior and posterior PAR domains is altered. Thus, RHO-1 activity appears to control the level of cortical contractility and concomitantly the size of cortical domains. These data support the idea that in C. elegans embryos the initial size of the PAR domains is set by regulating the contractile activity of the acto-myosin cytoskeleton through the activity of RHO-1. RGA-3/4 have functions different from CYK-4, the other known GAP required for the first cell division, showing that different GAPs cooperate to control the activity of the acto-myosin cytoskeleton in the first cell division of C. elegans embryos.

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 Dates: 2007
 Publication Status: Issued
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 Identifiers: eDoc: 348572
Other: 850
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Title: Proceedings of the National Academy of Sciences, USA
Source Genre: Journal
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Pages: - Volume / Issue: 104 (38) Sequence Number: - Start / End Page: 14976 - 14981 Identifier: -