English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze

Stanek, D., & Neugebauer, K. (2006). The Cajal body: a meeting place for spliceosomal snRNPs in the nuclear maze. Chromosoma, 115(5), 343-354.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Stanek, David1, Author           
Neugebauer, Karla1, Author           
Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

Content

show
hide
Free keywords: -
 Abstract: Spliceosomal small nuclear ribonucleoprotein particles (snRNPs) are essential pre-mRNA splicing factors that consist of small nuclear RNAs (snRNAs) complexed with specific sets of proteins. A considerable body of evidence has established that snRNP assembly is accomplished after snRNA synthesis in the nucleus through a series of steps involving cytoplasmic and nuclear phases. Recent work indicates that snRNPs transiently localize to the Cajal body (CB), a nonmembrane-bound inclusion present in the nuclei of most cells, for the final steps in snRNP maturation, including snRNA base modification, U4/U6 snRNA annealing, and snRNA-protein assembly. Here, we review these findings that suggest a crucial role for CBs in the spliceosome cycle in which production of new snRNPs-and perhaps regenerated snRNPs after splicing-is promoted by the concentration of substrates in this previously mysterious subnuclear organelle. These insights allow us to speculate on the role of nuclear bodies in regulating the dynamics of RNP assembly to maintain a functional pool of factors available for key steps in gene expression.

Details

show
hide
Language(s):
 Dates: 2006
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 311177
Other: 646
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Chromosoma
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 115 (5) Sequence Number: - Start / End Page: 343 - 354 Identifier: -