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  Influence of fast advective flows on pattern formation of Dictyostelium discoideum.

Eckstein, T., Vidal-Henriquez, E., Bae, A., Zykov, V. S., Bodenschatz, E., & Gholami, A. (2018). Influence of fast advective flows on pattern formation of Dictyostelium discoideum. PLoS One, 13(3): e0194859. doi:10.1371/journal.pone.0194859.

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March 28, 2018
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 Urheber:
Eckstein, Torsten1, Autor           
Vidal-Henriquez, Estefania1, Autor           
Bae, Albert1, Autor           
Zykov, Vladimir S.1, Autor           
Bodenschatz, Eberhard1, Autor                 
Gholami, Azam1, Autor           
Affiliations:
1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Zusammenfassung: We report experimental and numerical results on pattern formation of self-organizing Dictyostelium discoideum cells in a microfluidic setup under a constant buffer flow. The external flow advects the signaling molecule cyclic adenosine monophosphate (cAMP) downstream, while the chemotactic cells attached to the solid substrate are not transported with the flow. At high flow velocities, elongated cAMP waves are formed that cover the whole length of the channel and propagate both parallel and perpendicular to the flow direction. While the wave period and transverse propagation velocity are constant, parallel wave velocity and the wave width increase linearly with the imposed flow. We also observe that the acquired wave shape is highly dependent on the wave generation site and the strength of the imposed flow. We compared the wave shape and velocity with numerical simulations performed using a reaction-diffusion model and found excellent agreement. These results are expected to play an important role in understanding the process of pattern formation and aggregation of D. discoideum that may experience fluid flows in its natural habitat.

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Sprache(n): eng - English
 Datum: 2018-03-28
 Publikationsstatus: Online veröffentlicht
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1371/journal.pone.0194859
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Projektname : T. E. acknowledges Deutsche Forschungsgemeinschaft (DFG), project number GH 184/1-1. E.V.H. thanks the Deutsche Akademische Austauschdienst (DAAD), Research Grants—Doctoral Programs in Germany. A.G. acknowledges MaxSynBio Consortium, which is jointly funded by the Federal Ministry of Education and Research of Germany and the Max Planck Society. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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Titel: PLoS One
  Kurztitel : PLoS One
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Science
Seiten: 20 Band / Heft: 13 (3) Artikelnummer: e0194859 Start- / Endseite: - Identifikator: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850