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  Measurement of Transcutaneous Vague Nerve Stimulation in the Anesthetized Macaque by Ultra-High Field fMRI

Hartig, R., Vedoveli, A., Steudel, T., Oeltermann, A., Logothetis, N. K., & Evrard, H. C. (2017). Measurement of Transcutaneous Vague Nerve Stimulation in the Anesthetized Macaque by Ultra-High Field fMRI. Poster presented at 18th Conference of Junior Neuroscientists of Tübingen (NeNa 2017), Schramberg, Germany.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-00EE-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-00EF-2
Genre: Poster

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http://blog.neuromag.net/nena2017.html (Any fulltext)
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 Creators:
Hartig, Renee1, 2, Author              
Vedoveli, Ana1, 2, Author              
Steudel, Thomas1, 2, Author              
Oeltermann, Axel1, 2, Author              
Logothetis, Nikos K1, 2, Author              
Evrard, Henry C1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: The auricular branch of the vagus nerve is responsible for the transmission of sensory information from the ear's cymba concha to homeostatic brainstem nuclei and thalamic nuclei as well as the insular cortex. These centers are crucial for the representation and processing of interoceptive afferents. In a study using ultra-high-field fMRI, the auricular branch of the vagus nerve was transcutaneously stimulated using a current-source device supplying a pulse train of 30s stimulation (0.2-0.5mA) on followed by 30s stimulation off. Pulses were delivered to bipolar titanium electrode contacts positioned on the ear. A high frequency noise blocker was added to each electrode channel, facilitating greater signal-to-noise functional echo-planar imaging. The data were modeled to obtain activation maps related to the nerve stimulation and also the periods before and after stimulation. A contrast between stimulation on and off periods primarily elucidates correlated activity of the contralateral posterior primary interoceptive cortex. Comparing periods of stimulation and post-stimulation to the resting-state, the anterior insular and cingulate cortices as well as the thalamus and brainstem nuclei responsible for viscerosensory information processing were invariably activated. Such spatial-temporal patterns of subcortical activity may reflect the recruitment of high-order cortical centers and autonomic system modulation over periods of time exceeding that of stimulation.

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 Dates: 2017-10-16
 Publication Status: Published in print
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Title: 18th Conference of Junior Neuroscientists of Tübingen (NeNa 2017)
Place of Event: Schramberg, Germany
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Title: 18th Conference of Junior Neuroscientists of Tübingen (NeNa 2017)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 39 - 39 Identifier: -