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  Predictive mechanisms in stem cells: an in vitro system based method for testing carcinogenicity

Vilardell, M., & Herwig, R. (2014). Predictive mechanisms in stem cells: an in vitro system based method for testing carcinogenicity. In S. C. Sahu, & D. A. Casciano (Eds.), Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology (pp. 337-346). Hoboken, NJ: John Wiley & Sons, Ltd. doi:10.1002/9781118856017.ch18.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-01D2-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-01D4-E
Genre: Book Chapter

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 Creators:
Vilardell, Mireia1, Author              
Herwig, Ralf2, Author              
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              

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 Abstract: The identification of predictive patterns for toxicity from high‐throughput gene expression readouts in human in vitro assays is a fundamental goal of toxicogenomics. Reproducible and predictive assays based on stem cells have the potential to deliver such predictions in a more unbiased way than, for example, hepatocarcinoma cell lines. In this chapter, we describe the molecular characteristics of such a system built on a human embryonic stem‐cell‐derived assay for the liver. We report and extend published work that applied this assay for the first time to predict carcinogenicity induced by chemical compounds. We describe a bioinformatics approach that uses pathway‐wise expression patterns instead of gene‐wise expression patterns in order to identify predictive mechanisms for chemical carcinogenicity, and we show that such patterns are highly discriminative for the different toxicity classes of carcinogens.

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Language(s): eng - English
 Dates: 2014-04-182014-05-16
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/9781118856017.ch18
 Degree: -

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Title: Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology
Source Genre: Book
 Creator(s):
Sahu, Saura C. , Editor
Casciano, Daniel A. , Editor
Affiliations:
-
Publ. Info: Hoboken, NJ : John Wiley & Sons, Ltd
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 337 - 346 Identifier: ISBN: 9781118856017 (online) 9781118439265 (print)