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  Identification of QTL affecting resistance/susceptibility to acute Actinobacillus pleuropneumoniae infection in swine

Reiner, G., Bertsch, N., Hoeltig, D., Selke, M., Willems, H., Gerlach, G. F., et al. (2014). Identification of QTL affecting resistance/susceptibility to acute Actinobacillus pleuropneumoniae infection in swine. Mammalian Genome, 25(3-4), 180-191. doi:10.1007/s00335-013-9497-4.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-01DA-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-01DB-7
Genre: Journal Article

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 Creators:
Reiner, Gerald , Author
Bertsch, Natalie , Author
Hoeltig, Doris , Author
Selke, Martin , Author
Willems, Hermann , Author
Gerlach, Gerald Friedrich , Author
Tuemmler, Burkhard , Author
Probst, Inga , Author
Herwig, Ralf1, Author              
Drungowski, Mario, Author
Waldmann, Karl Heinz , Author
Affiliations:
1Bioinformatics (Ralf Herwig), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479648              

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Free keywords: Quantitative Trait Locus; Clinical Score; Quantitative Trait Locus Analysis; High Responder; Radiographic Score
 Abstract: Actinobacillus pleuropneumoniae is among the most important pathogens worldwide in pig production. The agent can cause severe economic losses due to decreased performance, acute or chronic pleuropneumonia and an increased incidence of death. Therapeutics cannot be used in a sustainable manner, and vaccination is not always available, but discovering more about host defence and disease mechanisms might lead to new methods of prophylaxis. The aim of the present study was to detect quantitative trait loci (QTL) associated with resistance/susceptibility to A. pleuropneumoniae. Under controlled conditions, 170 F2 animals of a Hampshire/Landrace family, with known differences in founder populations regarding A. pleuropneumoniae resistance, were challenged with an A. pleuropneumoniae serotype 7 aerosol followed by a detailed clinical, radiographic, ultrasonographic, pathological and bacteriological examination. F2 pigs were genotyped with 159 microsatellite markers. Significant QTL were identified on Sus scrofa chromosomes (SSC) 2, 6, 12, 13, 16, 17 and 18. They explained 6–22 % of phenotypic variance. One QTL on SSC2 reached significance on a genome-wide level for five associated phenotypic traits. A multiple regression analysis revealed a combinatory effect of markers SWR345 (SSC2) and S0143 (SSC12) on Respiratory Health Score, Clinical Score and the occurrence of death. The results indicate the genetic background of A. pleuropneumoniae resistance in swine and provide new insights into the genetic architecture of resistance/susceptibility to porcine pleuropneumonia. The results will be helpful in identifying the underlying genes and mechanisms.

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Language(s): eng - English
 Dates: 2014-01-212014-04
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00335-013-9497-4
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Title: Mammalian Genome
Source Genre: Journal
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Publ. Info: New York : Springer-Verlag
Pages: - Volume / Issue: 25 (3-4) Sequence Number: - Start / End Page: 180 - 191 Identifier: ISSN: 0938-8990
CoNE: https://pure.mpg.de/cone/journals/resource/954925571879