Structural Simplification of Bedaquiline: the Discovery of 
3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead 
Compounds

He, Chunxian; Preiss, Laura; Wang, Bin; Fu, Lei; Wen, Hui; Zhang, Xiang; Cui, Huaqing; Meier, Thomas; Yin, Dali

doi:10.1002/cmdc.201600441

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Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds

He, C., Preiss, L., Wang, B., Fu, L., Wen, H., Zhang, X., et al. (2017). Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-Dimethylaminomethyl)phenyl)quinoline-Derived Antitubercular Lead Compounds. ChemMedChem, 12, 106-119. doi:10.1002/cmdc.201600441.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-158B-B Version Permalink: https://hdl.handle.net/21.11116/0000-0001-158C-A

Genre: Journal Article

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Creators:
He, Chunxian^{1, 2}, Author
Preiss, Laura³, Author
Wang, Bin⁴, Author
Fu, Lei⁴, Author
Wen, Hui², Author
Zhang, Xiang², Author
Cui, Huaqing², Author
Meier, Thomas^{3, 5}, Author
Yin, Dali¹, Author

Affiliations:
1State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050 (China), ou_persistent22
2BeijingKey Laboratoryof ActiveSubstancesDiscoveryand Drugability-Evaluation,Institute of MateriaMedica,PekingUnionMedical Collegeand-ChineseAcademyof MedicalSciences,Beijing, 100050 (China), ou_persistent22
3Department of Structural Biology, Max Planck Institute of Biophysics, Max Planck Society, ou_2068291
4Departmentof Pharmacology,BeijingTuberculosisand Thoracic Tumor-Research Institute, Beijing Chest Hospital, Capital Medical University, 97 Ma Chang Street, Beijing 101149 (China), ou_persistent22
5Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ (UK), ou_persistent22

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Free keywords: ATP synthase, bedaquiline, multidrug resistance, Mycobacterium, tuberculosis, pulmonary tuberculosis

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Language(s): eng - English

Dates: Created: 2017Published Online: 2017

Publication Status: Published online

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Table of Contents: -

Rev. Type: Peer

Identifiers: DOI: 10.1002/cmdc.201600441

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Title: ChemMedChem

Other : ChemMedChem

Source Genre: Journal

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Publ. Info: Weinheim, Germany : Wiley-VCH

Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: 106 - 119 Identifier: ISSN: 1860-7179
CoNE: https://pure.mpg.de/cone/journals/resource/954925399508