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  Human leukocyte interferon produced by E. coli is biologically active

Goeddel, D. V., Yelverton, E., Ullrich, A., Heyneker, H. L., Miozzari, G., Holmes, W., et al. (1980). Human leukocyte interferon produced by E. coli is biologically active. Nature, 287(5781), 411-416. Retrieved from http://www.nature.com/nature/journal/v287/n5781/abs/287411a0.html.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-19A0-E Version Permalink: https://hdl.handle.net/21.11116/0000-0001-19A1-D
Genre: Journal Article

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Nature_287_1980_411.pdf (Any fulltext), 836KB
 
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https://www.nature.com/articles/287411a0.pdf (Any fulltext)
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https://doi.org/10.1038/287411a0 (Any fulltext)
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 Creators:
Goeddel, David V., Author
Yelverton, Elizabeth, Author
Ullrich, Axel, Author
Heyneker, Herbert L., Author
Miozzari, Guiseppe, Author
Holmes , William, Author
Seeburg, Peter H.1, Author           
Dull, Thomas, Author
May, Laurie, Author
Stebbing, Nowell, Author
Crea, Roberto, Author
Maeda, Shuichiro, Author
McCandliss, Russel, Author
Sloma, Alan, Author
Tabor, John M., Author
Gross, Mitchell, Author
Familletti, Phillip C., Author
Pestka, Sidney, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: A human leukocyte interferon cDNA was enzymatically synthesized, inserted into the vector pBR322, and cloned in Escherichia coli. The DNA sequence codes for a 23-amino acid signal peptide followed by an interferon polypeptide of 165 amino acids. An expression plasmid was constructed which permits the synthesis in E. coli of 2.5 x 10(8) units of interferon per litre of culture. This LeIF protected squirrel monkeys from lethal encephalomyocarditis virus infection.

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Language(s): eng - English
 Dates: 1980-07-021980-08-131980-10-021980-10-02
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: URI: http://www.nature.com/nature/journal/v287/n5781/abs/287411a0.html
URI: https://www.ncbi.nlm.nih.gov/pubmed/6159538
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 287 (5781) Sequence Number: - Start / End Page: 411 - 416 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238