Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

Sakmann, B., Patlak, J., & Neher, E. (1980). Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature, 286, 71-73. doi:10.1038/286071a0.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Nature_286_1980_71.pdf (beliebiger Volltext), 375KB
 
Datei-Permalink:
-
Name:
Nature_286_1980_71.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Sakmann, Bert1, Autor           
Patlak, J., Autor
Neher, Erwin, Autor
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: High resolution measurements of the current through individual ion channels activated by acetylcholine (AChR-channels) in frog muscle have shown that these currents are discrete pulse-like events with durations of a few milliseconds1,2. Fluctuation and relaxation measurements of end-plate currents have led to the conclusion that the rate of channel opening increases with agonist concentration, and that the channel, once open, closes spontaneously3–6. Katz and Thesleff have shown, however, that in the continued presence of ACh, the initial end-plate current declines to an equilibrium value with a time constant of several seconds7. This reversible phenomenon is referred to as receptor desensitization. We report here that in the presence of ACh concentrations sufficient to cause desensitization, single channel current pulses appear in groups. From the temporal sequence of the pulses, we have derived estimates of the rates of activation and desensitization of the AChR-channel.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 1979-11-121980-04-081980-07-03
 Publikationsstatus: Erschienen
 Seiten: 3
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/286071a0
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Nature
  Kurztitel : Nature
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 286 Artikelnummer: - Start- / Endseite: 71 - 73 Identifikator: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238