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  Respiration and the watershed of spinal CSF flow in humans.

Dreha-Kulaczewski, S., Konopka, M., Joseph, A. A., Kollmeier, J. M., Merboldt, K. D., Ludwig, H. C., et al. (2018). Respiration and the watershed of spinal CSF flow in humans. Scientific Reports, 8: 5594. doi:10.1038/s41598-018-23908-z.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-1BD2-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-4A93-4
Genre: Journal Article

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 Creators:
Dreha-Kulaczewski, S., Author
Konopka, M., Author
Joseph, A. A.1, Author              
Kollmeier, J. M.1, Author              
Merboldt, K. D.1, Author              
Ludwig, H. C., Author
Gärtner, J., Author
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society, ou_578634              

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 Abstract: The dynamics of human CSF in brain and upper spinal canal are regulated by inspiration and connected to the venous system through associated pressure changes. Upward CSF flow into the head during inspiration counterbalances venous flow out of the brain. Here, we investigated CSF motion along the spinal canal by real-time phase-contrast flow MRI at high spatial and temporal resolution. Results reveal a watershed of spinal CSF dynamics which divides flow behavior at about the level of the heart. While forced inspiration prompts upward surge of CSF flow volumes in the entire spinal canal, ensuing expiration leads to pronounced downward CSF flow, but only in the lower canal. The resulting pattern of net flow volumes during forced respiration yields upward CSF motion in the upper and downward flow in the lower spinal canal. These observations most likely reflect closely coupled CSF and venous systems as both large caval veins and their anastomosing vertebral plexus react to respiration-induced pressure changes.

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Language(s): eng - English
 Dates: 2018-04-04
 Publication Status: Published online
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 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-018-23908-z
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Title: Scientific Reports
Source Genre: Journal
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Pages: 7 Volume / Issue: 8 Sequence Number: 5594 Start / End Page: - Identifier: -