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  Characterization of pseudo‐continuous arterial spin labeling: Simulations and experimental validation

Lorenz, K., Mildner, T., Schlumm, T., & Möller, H. E. (2018). Characterization of pseudo‐continuous arterial spin labeling: Simulations and experimental validation. Magnetic Resonance in Medicine, 79(3), 1638-1649. doi:10.1002/mrm.26805.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-1C1E-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-A214-F
Genre: Journal Article

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 Creators:
Lorenz, Kathrin1, Author              
Mildner, Toralf1, Author              
Schlumm, Torsten1, Author              
Möller, Harald E.1, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              

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Free keywords: Arterial spin labeling (ASL); Pseudo‐continuous ASL (pCASL); Labeling efficiency; Perfusion imaging; Cerebral blood flow
 Abstract: Purpose To characterize pseudo‐continuous arterial spin labeling (pCASL) through simulations of spin inversion and to discuss suitable parameter settings for measuring cerebral perfusion. Methods Simulations of arterial spin inversion in pCASL were performed based on the Bloch equation. Both the labeling and the control condition of pCASL were analyzed separately, and the labeling efficiency, urn:x-wiley:07403194:media:mrm26805:mrm26805-math-0050, was calculated depending on the averages of both, the radiofrequency (RF) field amplitude and labeling gradient strength. The influence of additional parameters characterizing the pCASL pulse sequence, such as the interpulse interval, the RF duty cycle, and the labeling gradient, also were studied. An echo‐planar imaging protocol utilizing a short repetition time was developed for experimental validation by estimating α in the internal carotid artery. Results The effectiveness of the control condition of balanced pCASL crucially depends on both the labeling gradient amplitude and the RF duty cycle. The use of large values for both quantities improves the insensitivity to off‐resonance gradients caused by magnetic field inhomogeneities. In addition, balanced and unbalanced pCASL become comparably effective. Conclusion By use of appropriate parameter settings, labeling efficiencies of around 90% are feasible, independent of expected off‐resonance gradients at 3T.

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Language(s): eng - English
 Dates: 2017-05-292017-01-242017-05-302018-01-202018-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.26805
PMID: 28653470
Other: Epub 2017
 Degree: -

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Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)

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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 79 (3) Sequence Number: - Start / End Page: 1638 - 1649 Identifier: ISSN: 0740-3194
CoNE: /journals/resource/954925538149