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  Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults: A randomized controlled trial

Huhn, S., Beyer, F., Zhang, R., Lampe, L., Grothe, J., Kratzsch, J., et al. (2018). Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults: A randomized controlled trial. NeuroImage, 174, 177-190. doi:10.1016/j.neuroimage.2018.03.023.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-1E07-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-9787-A
Genre: Journal Article

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 Creators:
Huhn, Sebastian1, 2, Author              
Beyer, Frauke1, 2, Author              
Zhang, Rui1, 2, Author              
Lampe, Leonie1, Author              
Grothe, Jana1, Author
Kratzsch, Jürgen3, Author
Willenberg, Anja3, Author
Breitfeld, Jana4, Author
Kovacs, Peter4, Author
Stumvoll, Michael2, 4, Author
Trampel, Robert5, Author              
Bazin, Pierre-Louis5, 6, 7, Author              
Villringer, Arno1, 2, Author              
Witte, Veronica1, 2, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
3Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
6Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              
7The Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands, ou_persistent22              

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Free keywords: 7 Tesla MRI; Subjective cognitive decline; Resting-state fMRI; Mean diffusivity; Hippocampus subfields; Polyphenol
 Abstract: Introduction The polyphenol resveratrol has been suggested to exert beneficial effects on memory and the aging hippocampus due to calorie-restriction mimicking effects. However, the evidence based on human interventional studies is scarce. We therefore aimed to determine the effects of resveratrol on memory performance, and to identify potential underlying mechanisms using a broad array of blood-based biomarkers as well as hippocampus connectivity and microstructure assessed with ultra-high field magnetic resonance imaging (UHF-MRI). Methods In this double-blind, randomized controlled trial, 60 elderly participants (60–79 years) with a wide body-mass index (BMI) range of 21–37 kg/m2 were randomized to receive either resveratrol (200 mg/day) or placebo for 26 weeks (registered at ClinicalTrials.gov: NCT02621554). Baseline and follow-up assessments included the California Verbal Learning Task (CVLT, main outcome), the ModBent task, anthropometry, markers of glucose and lipid metabolism, inflammation and neurotrophins derived from fasting blood, multimodal neuroimaging at 3 and 7 T, and questionnaires to assess confounding factors. Results Multivariate repeated-measures ANOVA did not detect significant time by group effects for CVLT performance. There was a trend for preserved pattern recognition memory after resveratrol, while performance decreased in the placebo group (n.s., p = 0.07). Further exploratory analyses showed increases in both groups over time in body fat, cholesterol, fasting glucose, interleukin 6, high sensitive C-reactive protein, tumor necrosis factor alpha and in mean diffusivity of the subiculum and presubiculum, as well as decreases in physical activity, brain-derived neurotrophic factor and insulin-like growth factor 1 at follow-up, which were partly more pronounced after resveratrol.

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Language(s): eng - English
 Dates: 2018-03-032017-11-272018-03-122018-03-132018-07-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.neuroimage.2018.03.023
PMID: 29548848
Other: Epub 2018
 Degree: -

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Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : WI 3342/3–1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Max-Planck International Research Network on Aging (MaxNetAging)
Project name : -
Grant ID : 01EO1501
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)

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Title: NeuroImage
Source Genre: Journal
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Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 174 Sequence Number: - Start / End Page: 177 - 190 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166