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  Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone

Goeddel, D. V., Heyneker, H. L., Horzumi, T., Arentzen, R., Itakura, K., Yansura, D. G., et al. (1979). Direct expression in Escherichia coli of a DNA sequence coding for human growth hormone. Nature, 281(5732), 544-548. doi:10.1038/281544a0.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-22E5-6 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-22E6-5
Genre: Journal Article

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Nature_281_1979_544.pdf (Any fulltext), 588KB
 
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https://www.nature.com/articles/281544a0.pdf (Any fulltext)
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https://doi.org/110.1038/281544a0 (Any fulltext)
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 Creators:
Goeddel, David V., Author
Heyneker, Herbert L., Author
Horzumi, T., Author
Arentzen, Rene, Author
Itakura, Keiichi, Author
Yansura, Daniel G., Author
Ross, Michael J., Author
Miozzari, Guiseppe, Author
Crea, Roberto, Author
Seeburg, Peter H.1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: DNA coding for human growth hormone was constructed by using chemically synthesised DNA in conjunction with enzymatically prepared cDNA. This 'hybrid' gene was expressed in Escherichia coli under the control of the lac promoter. A polypeptide was produced having the size and immunological properties characteristic of mature human growth hormone.

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Language(s): eng - English
 Dates: 1979-07-061979-08-161979-10-18
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/281544a0
URI: https://www.ncbi.nlm.nih.gov/pubmed/386136
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 281 (5732) Sequence Number: - Start / End Page: 544 - 548 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238