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  Ultrafast CEST imaging

Döpfert, J., Zaiss, M., Witte, C., & Schröder, L. (2014). Ultrafast CEST imaging. Journal of Magnetic Resonance, 243, 47-53.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0001-2A0F-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0001-2A10-E
Genre: Journal Article

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Döpfert, J, Author
Zaiss, Moritz1, Author              
Witte, C, Author
Schröder, L, Author
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1German Cancer Research Center (DKFZ), Heidelberg, ou_persistent22              

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 Abstract: We describe a new MR imaging method for the rapid characterization or screening of chemical exchange saturation transfer (CEST) contrast agents. It is based on encoding the chemical shift dimension with an additional gradient as proposed in previous ultrafast CEST spectroscopy approaches, but extends these with imaging capabilities. This allows us to investigate multiple compounds simultaneously with an arbitrary sample tube arrangement. The technique requires a fast multislice readout to ensure the saturation is not lost during data acquisition due to relaxation. We therefore employ radial subsampling, acquiring only 10 projections per CEST image with a 128 × 128 matrix. To recover the images, we use a heuristic reconstruction algorithm that incorporates low rank and limited object support as prior knowledge. This way, we are able to acquire a spectral CEST data set consisting of 15 saturation offsets more than 16 times faster than compared with conventional CEST imaging.

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 Dates: 2014-06
 Publication Status: Published in print
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Title: Journal of Magnetic Resonance
Source Genre: Journal
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Pages: - Volume / Issue: 243 Sequence Number: - Start / End Page: 47 - 53 Identifier: -