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  Regulation of growth hormone gene expression: Synergistic effects of thyroid and glucocorticoid hormones

Martial, J. A., Seeburg, P. H., Guenzi, D., Goodman, H. M., & Baxter, J. D. (1977). Regulation of growth hormone gene expression: Synergistic effects of thyroid and glucocorticoid hormones. Proceedings of the National Academy of Sciences of the United States of America, 74(10), 4293-4295. Retrieved from http://www.jstor.org/stable/67722.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0001-2CF3-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-0001-2CF4-B
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PNAS_74_1977_4293.pdf (beliebiger Volltext), 953KB
 
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http://www.jstor.org/stable/pdf/67722.pdf?refreqid=excelsior%3Ada9e6b01ef70cf28fb1c2444c841edc8 (beliebiger Volltext)
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 Urheber:
Martial, Joseph A., Autor
Seeburg, Peter H.1, Autor           
Guenzi, D., Autor
Goodman, Howard M., Autor
Baxter , John D., Autor
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Zusammenfassung: Cultured rat pituitary cells (GC) respond to thyroid and glucocorticoid hormones by increases in growth hormone production and growth hormone mRNA. When these cells are transferred from medium containing normal animal serum (with 1.8 mug of thyroxine per dl) to a medium containing serum from a thyroidectomized calf, "hypothyroid medium" (with no detectable thyroid hormone), growth hormone production decreases markedly. In cells maintained for 5 days in hypothyroid medium, triiodothyronine induces within 50 hr a 17-fold increase in growth hormone production whereas glucocorticoids, during the same time, produce a negligible (3-fold or less) stimulation. In combination, the two hormones promote a 45-fold stimulation. In all instances the changes in growth hormone production are paralleled by changes in the levels of growth hormone mRNA as measured by cell-free translation. The transfer to hypothyroid medium and the hormonal induction do not affect the relative activities of other mRNAs whose products are detectable on polyacrylamide gels. These studies indicate that thyroid hormone can be an activator of the expression of the growth hormone gene. The results also show that triiodothyronine controls the magnitude of the effect of glucocorticoids on growth hormone mRNA, and provide a model for "permissive" triiodothyronine action. The synergistic effect of these two classes of hormone suggests that they increase levels of growth hormone mRNA by different mechanisms.

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Sprache(n): eng - English
 Datum: 1977-07-291977-10
 Publikationsstatus: Erschienen
 Seiten: 3
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: URI: http://www.jstor.org/stable/67722
URI: https://www.ncbi.nlm.nih.gov/pubmed/270674
URI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC431926/
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Titel: Proceedings of the National Academy of Sciences of the United States of America
  Andere : Proceedings of the National Academy of Sciences of the USA
  Andere : Proc. Acad. Sci. USA
  Andere : Proc. Acad. Sci. U.S.A.
  Kurztitel : PNAS
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Washington, D.C. : National Academy of Sciences
Seiten: - Band / Heft: 74 (10) Artikelnummer: - Start- / Endseite: 4293 - 4295 Identifikator: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230