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  Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions

Betz, W., & Sakmann, B. (1973). Effects of proteolytic enzymes on function and structure of frog neuromuscular junctions. Journal of Physiology, 230(3), 673-688. doi:10.1113/jphysiol.1973.sp010211.

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JPhysiol_230_1973_673.pdf (Any fulltext), 5MB
 
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 Creators:
Betz, William, Author
Sakmann, Bert1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: 1. Frog cutaneous pectoris nerve-muscle preparations were incubated with collagenase and protease and examined with electrophysiological and electron microscopic techniques.2. The physiological properties and intracellular ultrastructural appearance of individual muscle and nerve cells were not affected by the enzyme treatment. However, neuromuscular transmission and the morphology of the nerve-muscle junction were altered.3. Collagenase produced an irreversible loss of activity of end-plate cholinesterase and a partial loss of stainable ;synaptic cleft material'.4. Protease produced these changes and, in addition, the entire basement membrane was digested, which led to ;synaptic disjunction' of nerve terminals and muscle end-plates.

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Language(s): eng - English
 Dates: 1972-12-041973-05-01
 Publication Status: Published in print
 Pages: 22
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 Table of Contents: -
 Rev. Type: Peer
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Title: Journal of Physiology
Source Genre: Journal
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Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 230 (3) Sequence Number: - Start / End Page: 673 - 688 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693